Metabolism of phenacetin in combination drug.
نویسندگان
چکیده
منابع مشابه
Phenacetin
Of many reports on the use of phenacetin, one by Dr. Freidrich Miiller?" Therapeutische Monatshefte," August 1888, is of unusual merit. He made numerous trials of the remedy in various diseases, and found that the temperature in adults was lowered by doses of seven to eleven grains, and seldom as much as fifteen grains was used. The fall in the temperature occurred within from one to four hours...
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Phenacetin was first listed in the First Annual Report on Carcinogens (1980), as reasonably anticipated to be a human carcinogen, and analgesic mixtures containing phenacetin were first listed in the Fourth Annual Report on Carcinogens (1985), as known to be human carcinogens. The evidence for the carcinogenicity of these two substances is discussed separately; however, information on propertie...
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Numerous cytochrome P450 inhibitors have been described as effective modulators of cytochrome P450 isoforms activity in vitro. Their inhibitory efficiency may be considerably modified after in vivo application. The aim of this study was to examine the effect of oral administration of diallyl sulfide--a cytochrome P450 2E1 inhibitor and cimetidine--a cytochrome P450 2C6 and 2C11 inhibitor on rat...
متن کاملPreoperative Phenacetin Metabolism Test in the Prediction of Postoperative Liver Dysfunction of Patients with Hepatocellular Carcinoma
BACKGROUND The risk of postoperative liver dysfunction (PLD) in patients with injured livers, such as in hepatocellular carcinoma (HCC), is still not negligible. Phenacetin metabolism test can reflect hepatic functional reserve in patients with chronic hepatic damage. The aim of this study was to assess the ability of phenacetin metabolism test to predict PLD in patients with HCC receiving part...
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The CYP1A P450 subfamily consists of two members, CYP1A1 and CYP1A2 in mouse, rat, dog, monkey and human. CYP1A shows a quite strong conservation among species with an identity to human higher that 80% in rat (83 and 80%, respectively for CYP1A1 and CYP1A2), mouse (83 and 80%, respectively for CYP1A1 and CYP1A2), dog (84% for CYP1A2) and monkey (95% for both CYP1A1 and CYP1A2). Drug-drug intera...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1988
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.19.299